Drug Index

Etelcalcetide

 
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Mechanism :

Etelcalcetide, a synthetic peptide calcimimetic, allosterically activates the calcium-sensing receptor (CaSR) on the parathyroid gland, resulting in decreased PTH secretion, and serum calcium and phosphorus levels in patients with secondary hyperparathyroidism on hemodialysis.


Indication :

• Secondary hyperparathyroidism with chronic kidney disease (CKD) on hemodialysis


Contraindications :

Hypersensitivity to etelcalcetide or any component of the formulation.


Dosing :

Safety and efficacy not established in children.

Adults: IV: Initial: 5 mg IV bolus 3 times per week at the end of hemodialysis.


Adverse Effect :

Decreased serum calcium, hypophosphatemia, diarrhea, nausea, muscle spasm, prolonged Q-T interval on ECG, cardiac failure, hypocalcemia, vomiting, antibody development.


Interaction :

Cinacalcet: May enhance the hypocalcemic effect of Etelcalcetide.


07/14/2019 06:52:17 Etelcalcetide
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