Drug Index


Mechanism :

Fibrinogen (coagulation factor I), a protein found in normal plasma, is required to clot blood.

Indication :

  • Congenital fibrinogen deficiency

Contraindications :

Severe, immediate hypersensitivity reactions, including anaphylaxis to fibrinogen, human plasma-derived products, or any component of the formulation.

Dosing :

Maintain a target fibrinogen level of 100 mg/dL for minor bleeding and 150 mg/dL for major bleeding.
When baseline fibrinogen level is known:
Fibryga Dose (mg/kg) = [Target level (Mg/dL) - measured level (Mg/dL)] divided by 1.8 (Mg/dL per mg/kg body weight)
RiaSTAP Dose (mg/kg) = [Target level (Mg/dL) - measured level (Mg/dL)] divided by 1.7 (Mg/dL per mg/kg body weight)
When baseline fibrinogen level is not known:
70 mg/kg IV.

Adverse Effect :

Headache, erythema, pruritus, vomiting, weakness, fever.

Interaction :

No known significant interactions.

Hepatic Dose :

In patients with hepatic impairment, the potential benefit of treatment with human plasma fibrinogen should be weighed against the risk of thromboembolic complications. Use with caution and do close monitoring.
02/21/2024 21:50:01 Fibrinogen
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