Drug Index


Mechanism :

Sucralfate’s ability to accelerate healing of duodenal ulcers remains to be fully defined, it is known that it exerts its effect through a local, rather than systemic, action. Sucralfate forms an ulcer-adherent complex with proteinaceous exudate at the ulcer site.

Indication :

  • Stress ulcer prophylaxis
  • Esophageal and gastric variceal bleeding prophylaxis
  • Oesophagitis
  • Upper Gl bleed of unknown cause

Contraindications :

There are no known contraindications to the use of sucralfate.

Dosing :

The safety and efficacy in children under 14 years of age is not established.
10-20 mg/kg/PO 1 hour before meal (Max: 80 mg/kg/day PO or alternatively, up to 2000 mg/day PO).

Adverse Effect :

Constipation, nausea, gastric discomfort, indigestion, flatulence, dry mouth, pruritus, rash, dizziness, insomnia, sleepiness, vertigo, back pain, headache. Hypersensitivity reactions, including urticaria (hives), angioedema, respiratory difficulty.

Interaction :

Potassium Acid Phosphate/Potassium Phosphate: Combination may decrease phosphate efficacy.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-504 g daily
10-202–4 g daily
<102–4 g daily

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDNot dialysed. Dose as in GFR=10– 20 mL/min

Hepatic Dose :

No dose adjustment recommended.
02/14/2024 22:08:47 Sucralfate
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