Drug Index


Mechanism :

Domperidone is an antidopaminergic drug, and is used orally, rectally or intravenously to suppress nausea and vomiting. It has also been used to stimulate lactation.

Indication :

  • Vomiting
  • Gastroesophageal reflux disease (GERD)

Contraindications :

Contraindicated in patients with known hypersensitivity to domperidone, in the presence of gastro-intestinal haemorrhage, obstruction or perforation and in patients with a prolactin-releasing pituitary tumour. Prolonged QT-intervals have been seen in neonates.

Dosing :

1 month-12 years:
200-400 microgram/kg/dose 3-4 times a day before food.
12-18 years:
10-20 mg 3-4 times a day.

Adverse Effect :

Dystonic reactions, reversible raised serum prolactin levels that may lead to galactorrhoea and gynaecomastia, hypertensive crises in patients with pheochromocytoma, urticaria and abdominal cramps.

Interaction :

Anti-cholinergic drugs: May inhibit the anti-dyspeptic effects.
Anti-muscarinic agents and opioid analgesics: May antagonise the effect.
May enhance the absorption of concurrently administered drugs.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDUnlikely to be dialysed. Dose as in normal renal function
HDF/High fluxUnlikely to be dialysed. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Mild impairment: There are no dosage adjustments provided in the manufacturer’s labelling. Use with caution as it undergoes hepatic metabolism.
Moderate or severe impairment: Use is contraindicated.
03/20/2024 11:07:22 Domperidone
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