Drug Index



Mechanism :

Glutamine regulates GI cell growth, function, and regeneration in short bowel syndrome. Glutamine is considered a "conditionally essential" amino acid during metabolic stress and injury. Glutamine is a precursor for nicotinamide adenine dinucleotide (NAD).

Indication :

• Short bowel syndrome

• Sickle cell disease

• Nutritional supplement

Contraindications :

Renal or liver impairment; Reye syndrome; shock; multi-organ failure.

Dosing :

Sickle cell disease:

Oral: Children ≥5 years and Adolescents:

<30 kg: 5 g twice daily.

30 to 65 kg: 10 g twice daily.

>65 kg: 15 g twice daily.

Supplement (nutritional):

Oral: 0.25 to 0.5 g/kg/day given in 3 divided doses.

Adverse Effect :

Chest pain, headache, constipation, nausea, abdominal pain, limb pain, cough.

Interaction :

Lactulose: Glutamine may diminish the therapeutic effect of Lactulose. Specifically, glutamine may diminish the ammonia-lowering effects of lactulose.

Hepatic Dose :

No dosage adjustments are needed.
04/11/2020 16:05:53 Glutamine
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