Drug Index

Golimumab

 
print

Mechanism :

Human monoclonal antibody that binds to human tumor necrosis factor alpha (TNFa), thereby interfering with endogenous TNFa activity.


Indication :

• Psoriatic arthritis

• Polyarticular Juvenile Idiopathic arthritis

• Ulcerative colitis


Contraindications :

Hypersensitivity to golimumab, latex, or any other component of formulation or packaging; patients with severe infections (e.g., sepsis, tuberculosis, opportunistic infections); moderate or severe heart failure (NYHA class III/IV).


Dosing :

<18 years: Safety and efficacy not established.

Adult dosing: 50 mg SC monthly. In ulcerative colitis, start 200 mg SC, then 100 mg SC after 2 weeks and then 100 mg SC every 4 weeks.


Adverse Effect :

Injections site reaction, viral infections, Positive ANA titre, increased AST/ALT, dizziness, paresthesia.


Interaction :

Abatacept, Anakinra: Anti-TNF Agents may enhance the adverse/toxic effect. An increased risk of serious infection during concomitant use has been reported.
Belimumab: Monoclonal Antibodies may enhance the adverse/toxic effect of Belimumab.
Canakinumab: Anti-TNF Agents may enhance the adverse/toxic effect of Canakinumab. Specifically, the risk for serious infections and/or neutropenia may be increased.
Leflunomide: Immunosuppressants may enhance the adverse/toxic effect of Leflunomide.
Thiopurine Analogs: Anti-TNF Agents may enhance the adverse/toxic effect of Thiopurine Analogs. Specifically, the risk for T-cell non-Hodgkin's lymphoma (including hepatosplenic T-cell lymphoma) may be increased.
Tocilizumab: May enhance the immunosuppressive effect of Anti-TNF Agents.
Vaccines (Live): Avoid use of live organism vaccines with immunosuppressants; live-attenuated vaccines should not be given for at least 3 months after immunosuppressants.


07/18/2019 01:57:44 Golimumab
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0