Drug Index

Gonadotropin releasing Hormone

 
print
Synonyms :

GnRH, Leuprolide, Leuprolide Acetate, Leuprorelin Acetate

Mechanism :

GNRH stimulates the release of the pituitary gonadotropins, LH and FSH, resulting in a temporary increase of gonadal steroidogenesis. Repeated dosing abolishes the stimulatory effect on the pituitary gland.


Indication :

• Central precocious puberty in children


Contraindications :

Contraindicated in children <1 year of age as diluent contains benzyl alcohol.

Also contraindicated in hypersensitivity to GnRH, GnRH agonist analogs, undiagnosed abnormal vaginal bleeding, pregnancy or women who may become pregnant while receiving the drug, women who are breast-feeding.


Dosing :

Not to be given to children under two years of age.

Leuprolide acetate:

Start: 50 mcg/kg/day subcutaneously, may increase by 10 mcg/kg/day until total downregulation; Discontinue with onset of puberty.

Depot preparation monthly:

<25 kg: 7.5 mg IM every month.

>25 kg to 37.5 kg: 11.25 mg IM every month.

>37.5 kg: 15 mg IM every month.

Assess response 1-2 months after first injection; increase next monthly dose to the next higher level, if adequate hormonal and clinical suppression not achieved with starting doses.

Depot preparation every 3 month:

11.25 mg or 30 mg as single IM injection every 3 months. Assess response 2-3 months and 6 months after injection.


Adverse Effect :

Common Reactions: Hot flashes/diaphoresis, tumor flare, transient headache, generalized pain, joint disorder, dyspepsia, edema, weight changes, dizziness, breast tenderness/gynecomastia, injection site reaction, insomnia, urogenital disorders, paraesthesia, neuromuscular disorder, asthenia.

Serious Reactions: Anaphylaxis, bone density loss, depression, suicidal tendency, pituitary apoplexy, seizures, hepatotoxicity, QT prolongation (long-term use).


Interaction :

Phenothiazines, Metoclopramide and Digoxin: Response may be blunted by medicines causing a rise in prolactin.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function Monitor closely

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDUnlikely to be dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
08/05/2020 08:05:58 Gonadotropin releasing Hormone
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0