Drug Index

Growth Hormone

 
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Synonyms :

Genotropin, Humatrope, Norditropin, Omnitrope, Somatropin

Mechanism :

Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH. This leads to the normalization of serum IGF-1 levels.


Indication :

• Short stature due to growth hormone deficiency

• Turner’s syndrome

• Prader Willi syndrome

• Noonan Syndrome

• CRF

• Homeobox containing gene

• Small for gestational age


Contraindications :

Hypersensitivity to drug/class/component

Caution if hepatic impairment, elevated lfts, gh secreting tumors, diabetes mellitus.


Dosing :

Growth hormone deficiency:

Norditropin:

0.17-0.24 mg/kg/week (0.0024-0.034 mg/kg/day) subcutaneously in 6-7 equal divided doses per week.

Genotropin, Omnitrope:

0.16-0.3 mg/kg/week subcutaneously in 6-7 equal divided doses per week.

Humatrope:

0.18-0.24 mg/kg/week subcutaneously in 6-7 equal divided doses per week.


Adverse Effect :

local lipoatrophy, hypothyroidism, pain in hip and knee, edema, hypersensitivity reactions, increase in cutaneous nevi, slipped capital femoral epiphysis, hypothyroidism, hyperglycemia, pancreatitis, leukemia.


Interaction :

Hypoglycemic Agents or Insulin Injections: Monitoring required if the patient is given Oral Hypoglycemic Agents or insulin injections.


08/11/2019 20:50:05 Growth Hormone
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