Hydroxyethyl Starch
Synonyms :
HES, Hespan
Mechanism :
Hydroxyethyl starch (HES) is one of the most frequently used plasma substitutes. Recent studies have indicated that HES may reduce capillary leakage.
Indication :
- Treatment of hypovolemia & shock
Contraindications :
Known hypersensitivity to starch or related products.
Dosing :
10 mL/kg/dose IV.
Maximum dose of 20 mL/kg IV.
Adverse Effect :
Anaphylactic reactions including urticaria, wheezing, periorbital edema, mild temperature elevation, chills, headache, flu-like symptoms, pruritus, myalgia, vomiting, peripheral edema, salivary gland enlargement, prolonged bleeding time, increase in serum amylase levels during infusion.
Interaction :
Propofol, under study.
Hepatic Dose :
There are no dosage adjustments provided in manufacturer’s labeling; use is contraindicated in severe impairment.