Histaglobulin
Mechanism :
Histaglobulin is a lyophilised preparation of Histamine coupled with Human Normal Immunoglobulin. Histaglobulin administered subcutaneously induces production of antibody against the histamine-immunoglobulin complex, which binds and inactivates histamine released during allergy. Repeated doses of histaglobulin increase this antibody titer, for which booster doses of histaglobulin were administered every 6 months.
Indication :
- Pruritus
- Eczema
- Allergic Rhinitis
- Bronchial Asthma
- Urticaria
- Atopic Dermatitis
Contraindications :
Hypersensitivity to histaglobulin is a contraindication.
Dosing :
Available as Human normal immunoglobulin (12 mg) and histamine dihydrochloride (0.15 mcg).
3 injections of 12 mg each SC at an interval of 7 days.
Adverse Effect :
May give rise to mild local reactions, fever, chills, malaise.
Interaction :
MMR: Measles, mumps and rubella vaccines should not be given 3 weeks before to 3 months after using this drug, as their efficacy may be reduced.
Immunoglobulin: Administration of any immunoglobulin preparation may raise antibody levels to a number of microorganisms, and this is important when interpreting antibody assays within 2-3 months of administration of this drug.
Hepatic Dose :
No dosage adjustments are recommended.