Drug Index

Interferon Gamma

 
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Mechanism :

Interferons are a family of naturally occurring proteins, which have molecular weights ranging from 15,000 to 21,000 daltons. Three major classes of interferons have been identified: alfa, beta, and gamma. Interferon beta-1b, interferon alfa, and interferon gamma have overlapping yet distinct biologic activities.


Indication :

• Chronic granulomatous disease


Contraindications :

Contraindicated in patients who have hypersensitivity to interferon gamma or known hypersensitivity to closely related interferons. Use with caution in seizure disorders and/or compromised CNS function; pre-existing cardiac disease, e.g. ischemia, congestive heart failure and arrhythmias; severe hepatic or renal impairment. Monitor before and during treatment; hematological tests (including FBC, differential white cell count and platelet count), blood chemistry tests (including renal and liver function tests) and urinalysis.


Dosing :

For Body Surface Area >0.5m²: 50 microgram per sqm given subcutaneously thrice a week.

For Body Surface Area <0.5m²: 1.5 microgram per m² given subcutaneously thrice a week.


Adverse Effect :

Commonly reported adverse effects are fever, headache, chills, myalgia or fatigue, diarrhea, nausea and vomiting, arthralgia, rashes and injection-site reactions.


Interaction :

Serum pro­tein preparations or immunological preparations (e.g. vaccines): Simultaneous administration should be avoided because of the risk for unex­pected amplified immune response.


07/18/2019 12:46:51 Interferon Gamma
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