Drug Index

Meclofenamate

 
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Mechanism :

Reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties.


Indication :

• Juvenile arthritis, osteoarthritis and rheumatoid arthritis- pain relief

• Bursitis/tendinitis of the shoulder

• Fever

• Pain relief in primary dysmenorrhea/excessive menstrual blood loss


Contraindications :

Known hypersensitivity to meclofenamate or any component of the formulation; history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.


Dosing :

>14 years

Pain: Oral

200 to 400 mg daily in 3 to 4 equally divided dose maximum dose: 400 mg/day. Maximal benefit may not be seen for 2 to 3 weeks.

Primary dysmenorrhea/excessive menstrual blood loss: Oral

100 mg 3 times daily for up to 6 days, starting at the onset of menstrual flow.


Adverse Effect :

Dizziness, skin rash, abdominal cramps, dyspepsia, headache, pruritus, fluid retention, vomiting.


Interaction :

Anticoagulants: Agents with Antiplatelet Properties may enhance the anticoagulant effect of Anticoagulants.
Apixaban: Nonsteroidal Anti-Inflammatory Agents (Nonselective) may enhance the adverse/toxic effect of Apixaban.
Quinolones: Nonsteroidal Anti-Inflammatory Agents may enhance the neuroexcitatory and/or seizure-potentiating effect of Quinolones.
Vancomycin: Nonsteroidal Anti-Inflammatory Agents may increase the serum concentration of Vancomycin.


07/19/2019 03:12:44 Meclofenamate
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