Drug Index


Mechanism :

Reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties.

Indication :

  • Juvenile arthritis, osteoarthritis and rheumatoid arthritis- pain relief
  • Bursitis/tendinitis of the shoulder
  • Fever
  • Pain relief in primary dysmenorrhea/excessive menstrual blood loss

Contraindications :

Known hypersensitivity to meclofenamate or any component of the formulation; history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.

Dosing :

>14 years
Oral: 200 to 400 mg daily in 3 to 4 equally divided dose maximum dose: 400 mg/day. Maximal benefit may not be seen for 2 to 3 weeks.
Primary dysmenorrhea/excessive menstrual blood loss:
Oral: 100 mg 3 times daily for up to 6 days, starting at the onset of menstrual flow.

Adverse Effect :

Dizziness, skin rash, abdominal cramps, dyspepsia, headache, pruritus, fluid retention, vomiting.

Interaction :

Anticoagulants: Agents with Antiplatelet Properties may enhance the anticoagulant effect of Anticoagulants.
Apixaban: Nonsteroidal Anti-Inflammatory Agents (Nonselective) may enhance the adverse/toxic effect of Apixaban.
Quinolones: Nonsteroidal Anti-Inflammatory Agents may enhance the neuroexcitatory and/or seizure-potentiating effect of Quinolones.
Vancomycin: Nonsteroidal Anti-Inflammatory Agents may increase the serum concentration of Vancomycin.

Hepatic Dose :

No dosage adjustments are recommended.
01/21/2024 09:21:41 Meclofenamate
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