Drug Index

Meropenem/Vaborbactam

 
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Mechanism :

Meropenem: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins
Vaborbactam is a beta-lactamase inhibitor that protects meropenem from degradation by certain serine beta-lactamases (e.g., K. pneumonia carbapenemase [KPC]).


Indication :

• Treatment of complicated urinary tract infections (cUTI), including pyelonephritis, caused by susceptible Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae species complex in patients =18 years of age.


Contraindications :

Hypersensitivity to meropenem, vaborbactam, other carbapenems or beta-lactamase inhibitors, or any component of the formulation; patients who have demonstrated anaphylactic reactions to beta-lactam antibacterial agents.


Dosing :

Safety and efficacy not established in pediatric population.

Adults:

4 g (2 g meropenem and 2 g vaborbactam) IV every 8 hours for up to 14 days.


Adverse Effect :

Phlebitis, headache, hypokalemia, diarrhea, nausea, increased serum AST/ALT, hypersensitivity, infusion site reaction, fever.


Interaction :

Probenecid: May increase the serum concentration of Meropenem.
Valproate Products: Carbapenems may decrease the serum concentration of Valproate Products.
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate.


08/08/2019 17:34:21 Meropenem/Vaborbactam
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