Drug Index

Methohexital

 
print

Mechanism :

Methohexital is an ultra-short-acting IV barbiturate anaesthetic.


Indication :

• Induction of anaesthesia

• Procedural sedation

• Off-Label: Wada test


Contraindications :

Hypersensitivity to methohexital or any component of the formulation; patients in whom general anaesthesia is contraindicated.


Dosing :

Induction of anaesthesia:

≥1 month:

IM: 6.6 to 10 mg/kg of 5% solution

Rectal: 25 mg/kg of a 1% solution

Procedural sedation: IV:

Initial: 0.5 mg/kg of a 1% solution given immediately prior to procedure.


Adverse Effect :

Circulatory depression, circulatory shock, hypotension, Anxiety, delirium (emergence), headache, involuntary muscle movements, erythema, pruritus, Abdominal pain, hiccups, nausea, Increased serum transaminases, Apnea, bronchospasm, cough, dyspnea.


Interaction :

Calcium Channel Blockers: Barbiturates may increase the metabolism of Calcium Channel Blockers.
CNS Depressants: May enhance the adverse/toxic effect of other CNS Depressants.
Estrogen Derivatives & progestins: Barbiturates may diminish the therapeutic effect of Estrogen Derivatives and progestins.
Opioid Analgesics: CNS Depressants may enhance the CNS depressant effect of Opioid Analgesics.
Selective Serotonin Reuptake Inhibitors: CNS Depressants may enhance the adverse/toxic effect of Selective Serotonin Reuptake Inhibitors.
Tricyclic Antidepressants: Barbiturates may increase the metabolism of Tricyclic Antidepressants.


07/18/2019 02:42:50 Methohexital
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0