Drug Index


Mechanism :

Metyrapone inhibits 11 beta-hydroxylase, preventing the conversion of 11-deoxycortisol to cortisol.

Indication :

  • ACTH function testing: Diagnostic test for hypothalamic-pituitary ACTH function
  • Off-label: Cushing Syndrome

Contraindications :

Hypersensitivity to metyrapone or any component of the formulation; patient with adrenal cortical insufficiency.

Dosing :

ACTH function testing:
Single-dose/overnight test:
30 mg/kg PO (Maximum: 3 g) at midnight.
Multiple-dose test:
15 mg/kg (Minimum: 250 mg; maximum: 750 mg) PO every 4 hours for 6 doses.

Adverse Effect :

Hypotension, dizziness, headache, sedation, allergic skin rash, abdominal discomfort, nausea, vomiting, bone marrow depression.

Interaction :

Acetaminophen: Metyrapone may increase the serum concentration of Acetaminophen.
Phenytoin and Fosphenytoin: May decrease the serum concentration of Metyrapone.

Hepatic Dose :

No dose adjustments are recommended.
03/23/2024 05:28:56 Metyrapone
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