Drug Index

Metyrapone

 
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Mechanism :

Metyrapone inhibits 11 beta-hydroxylase, preventing the conversion of 11-deoxycortisol to cortisol.


Indication :

• ACTH function testing: Diagnostic test for hypothalamic-pituitary ACTH function

• Off-label: Cushing Syndrome


Contraindications :

Hypersensitivity to metyrapone or any component of the formulation; patient with adrenal cortical insufficiency.


Dosing :

ACTH function testing:

Single-dose/overnight test: 30 mg/kg PO (Maximum: 3 g) at midnight.

Multiple-dose test: 15 mg/kg (Minimum: 250 mg; maximum: 750 mg) PO every 4 hours for 6 doses.


Adverse Effect :

Hypotension, dizziness, headache, sedation, allergic skin rash, abdominal discomfort, nausea, vomiting, bone marrow depression.


Interaction :

Acetaminophen: Metyrapone may increase the serum concentration of Acetaminophen.
Phenytoin and Fosphenytoin: May decrease the serum concentration of Metyrapone.


07/18/2019 09:40:52 Metyrapone
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