Drug Index

Montelukast

 
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Mechanism :

Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene CysLT1 receptor.


Indication :

• Asthma prophylaxis - add on therapy

• Exercise induced asthma

• Allergic rhinitis


Contraindications :

Contraindicated in patients with any previous sensitivity to montelukast. Not used to treat acute asthma attacks and cannot substitute inhaled or oral corticosteroids. Monitor for eosinophilia, vasculitic rash, worsening of pulmonary symptoms, cardiac complications and neuropathy.


Dosing :

Asthma, Perennial/seasonal allergic rhinitis:

Oral: Once daily in the evening

1-6 years: 4 mg

6-15 years: 5 mg

>15 years: 10 mg

Exercise induced bronchospasm:

6-15 years: 5 mg orally, 2 hours before exercise.

>15 years: 10 mg orally, 2 hours before exercise.


Adverse Effect :

Fever, headache, rash, influenza, nausea, diarrhoea, dyspepsia.


Interaction :

Phenytoin, Phenobarbital and Rifampicin: co-administered with CYP 3A4 inducers; plasma levels of montelukast may be decreased.


07/19/2019 03:48:57 Montelukast
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