Drug Index



Mechanism :

Moxidectin, an anti-helminthic agent, binds to glutamate-gated chloride ions channels, gamma-aminobutyric acid (GABA) receptors, and/or APT-binding cassette transporters. This leads to increased permeability, influx of chloride ions, hyperpolarization, and muscle paralysis.

Indication :

• Treatment of onchocerciasis due to Onchocerca volvulus in patients =12 years of age.

Contraindications :

No contraindications

Dosing :

≥12 years: Oral: 8 mg as a single dose.

Adverse Effect :

Tachycardia, postural orthostatic tachycardia, hypotension, peripheral edema, headache, chills, lymph node pain, dizziness, pruritus, skin rash, hyponatremia, abdominal pain, diarrhea, eosinophilia, lymphocytopenia, neutropenia, musculoskeletal pain, flu-like symptoms, cough, fever.

Interaction :

No known significant interactions.

10/23/2019 14:01:58 Moxidectin
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