Drug Index


Mechanism :

Inhibits trypanothione reductase, a parasite-specific antioxidant defence enzyme.

Indication :

  • American Trypanosomiasis (Orphan drug)

Contraindications :

Active or history of peripheral neuropathy, Active or history of seizures & cerebral impairment, such as behavioural disorders, epilepsy, or psychoses, Hepatic or renal impairment.

Dosing :

1-10 years:
15-20 mg/kg/day every 8 hours.
11-16 years:
12.5-15 mg/kg/day every 8 hours.
90 days.

Adverse Effect :

Anorexia, ataxia, convulsions, depression, fatigue, headache, memory impairment, paresthesia, sleep disorder, tremor, polyneuritis, weakness, rash, vomiting, myalgia, pulmonary infiltrates.

Interaction :

No known interactions.

Hepatic Dose :

Contraindicated in severe hepatic failure.
01/19/2024 02:08:12 Nifurtimox
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