Drug Index

Nifurtimox

 
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Mechanism :

Inhibits trypanothione reductase, a parasite-specific antioxidant defence enzyme.


Indication :

• American Trypanosomiasis (Orphan drug)


Contraindications :

Active or history of peripheral neuropathy, Active or history of seizures & cerebral impairment, such as behavioural disorders, epilepsy, or psychoses, Hepatic or renal impairment.


Dosing :

Oral: 1-10 years: 15-20 mg/kg/day every 8 hours.

11-16 years: 12.5-15 mg/kg/day every 8 hours.

Duration: 90 days.


Adverse Effect :

Anorexia, ataxia, convulsions, depression, fatigue, headache, memory impairment, paresthesia, sleep disorder, tremor, polyneuritis, weakness, rash, vomiting, myalgia, pulmonary infiltrates.


Interaction :

No known interactions.


07/18/2019 12:33:37 Nifurtimox
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