Drug Index

Nitric Oxide

 
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Mechanism :

Nitric oxide gas is a drug administered by inhalation. Nitric oxide relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3´,5´-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide produces pulmonary vasodilation.


Indication :

• Hypoxic respiratory failure

• Chronic lung disease prevention

• Cystic fibrosis


Contraindications :

Contraindicated in the treatment of neonates known to be dependent on right-to-left shunting of blood.


Dosing :

Hypoxic respiratory failure: >34 weeks gestation: Start at 20 ppm, inhaled for upto 2 weeks.


Adverse Effect :

Methemoglobinemia, hypotension, withdrawal, pulmonary edema.


Interaction :

Sodium nitroprusside and nitroglycerin: May have an additive effect with the risk of developing methemoglobinemia.
Prilocaine: An increased risk of methemoglobinemia.


07/17/2019 10:45:17 Nitric Oxide
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