Drug Index

Nitric Oxide

Mechanism :

Nitric oxide gas is a drug administered by inhalation. Nitric oxide relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3´,5´-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide produces pulmonary vasodilation.

Indication :

  • Hypoxic respiratory failure
  • Chronic lung disease prevention
  • Cystic fibrosis

Contraindications :

Contraindicated in the treatment of neonates known to be dependent on right-to-left shunting of blood.

Dosing :

Hypoxic respiratory failure:
>34 weeks gestation: Start at 20 ppm, inhaled for upto 2 weeks.

Adverse Effect :

Methemoglobinemia, hypotension, withdrawal, pulmonary edema.

Interaction :

Sodium nitroprusside and nitroglycerin: May have an additive effect with the risk of developing methemoglobinemia.
Prilocaine: An increased risk of methemoglobinemia.

Hepatic Dose :

No dosage adjustments are recommended.
03/23/2024 05:06:45 Nitric Oxide
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