Drug Index

Nizatidine

 
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Mechanism :

Competitive inhibition of histamine at H2-receptors of the gastric parietal cells, thus inhibits gastric acid secretion.


Indication :

• Duodenal ulcer

• Benign Gastric ulcer

• Gastroesophageal reflux disease


Contraindications :

Hypersensitivity to nizatidine, other H2 antagonists, or any component of the formulation.


Dosing :

GERD:

≥12 years: 150 mg PO twice daily for up to 8 weeks. Maximum: 300 mg/day.

6 months-11 years (off-label use): 5-10 mg/kg/day PO in divided doses twice daily for up to 8 weeks.


Adverse Effect :

Headache, anxiety, dizziness, pruritus, skin rash, abdominal pain, anorexia, constipation, diarrhea, flatulence, cough, nasal congestion, fever.


Interaction :

Cefpodoxime: Histamine H2 Receptor Antagonists may decrease the absorption of Cefpodoxime.

Indinavir: Histamine H2 Receptor Antagonists may decrease the serum concentration of Indinavir.

Ketoconazole, Itraconazole: Histamine H2 Receptor Antagonists may decrease the serum concentration of ketoconazole, itraconazole.


07/15/2019 05:49:38 Nizatidine
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