Drug Index

Obiltoxaximab

 
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Mechanism :

Obiltoxaximab is a monoclonal antibody that binds the free protective antigen component of B. anthracis toxin thereby preventing the intracellular entry of the anthrax lethal factor and edema factor.


Indication :

• Prophylaxis & treatment of inhalational anthrax due to Bacillus anthracis in combination with appropriate antibacterial drugs.


Contraindications :

No contraindications.


Dosing :

IV

≤15 kg: 32 mg/kg/dose as a single dose.

>15 kg to 40 kg: 24 mg/kg/dose as a single dose.

>40 kg: 16 mg/kg/dose as a single dose.

Note: Premedicate with diphenhydramine prior to infusion.


Adverse Effect :

Headache, chest discomfort, chest pain, dizziness, fatigue. Skin rash, pruritus, urticarial, vomiting, lymphocytopenia, neutropenia, hypersensitivity reactions, antibody development, infusion site reaction, limb pain, increased CPK, cough, fever.


Interaction :

No known significant interactions.


07/18/2019 09:17:41 Obiltoxaximab
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