Drug Index

Mechanism :

Obiltoxaximab is a monoclonal antibody that binds the free protective antigen component of B. anthracis toxin thereby preventing the intracellular entry of the anthrax lethal factor and edema factor.

Indication :

  • Prophylaxis & treatment of inhalational anthrax due to Bacillus anthracis in combination with appropriate antibacterial drugs.

Contraindications :

No contraindications.

Dosing :

≤15 kg:
32 mg/kg/dose as a single dose.
>15 kg to 40 kg:
24 mg/kg/dose as a single dose.
>40 kg:
16 mg/kg/dose as a single dose.
Note: Premedicate with diphenhydramine prior to infusion.

Adverse Effect :

Headache, chest discomfort, chest pain, dizziness, fatigue. Skin rash, pruritus, urticarial, vomiting, lymphocytopenia, neutropenia, hypersensitivity reactions, antibody development, infusion site reaction, limb pain, increased CPK, cough, fever.

Interaction :

No known significant interactions.

Hepatic Dose :

No dosage adjustments are recommended.
09/28/2020 07:05:39 Obiltoxaximab
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