Penciclovir
Mechanism :
Penciclovir triphosphate inhibits HSV polymerase competitively with deoxyguanosine triphosphate, thereby inhibiting herpes viral DNA synthesis.
Indication :
- Topical treatment of recurrent herpes labialis (cold sores)
Contraindications :
Hypersensitivity to the penciclovir or any component of the formulation.
Dosing :
≥12 years:
Apply cream (1%) at the first appearance of cold sore every 2 hours during waking hours for 4 days.
Adverse Effect :
Erythema, headache, application site reaction, altered sense of smell, erythematous rash, local anaesthesia, localized edema, oropharyngeal edema, pain, paresthesia, pruritus.
Interaction :
Talimogene Laherparepvec: Antiherpetic Antivirals may diminish the therapeutic effect of Talimogene Laherparepvec.
Hepatic Dose :
No dose adjustment recommended.