Drug Index


Mechanism :

Penciclovir triphosphate inhibits HSV polymerase competitively with deoxyguanosine triphosphate, thereby inhibiting herpes viral DNA synthesis.

Indication :

  • Topical treatment of recurrent herpes labialis (cold sores)

Contraindications :

Hypersensitivity to the penciclovir or any component of the formulation.

Dosing :

≥12 years:
Apply cream (1%) at the first appearance of cold sore every 2 hours during waking hours for 4 days.

Adverse Effect :

Erythema, headache, application site reaction, altered sense of smell, erythematous rash, local anaesthesia, localized edema, oropharyngeal edema, pain, paresthesia, pruritus.

Interaction :

Talimogene Laherparepvec: Antiherpetic Antivirals may diminish the therapeutic effect of Talimogene Laherparepvec.

Hepatic Dose :

No dose adjustment recommended.
01/23/2024 11:15:45 Penciclovir
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