Drug Index


Mechanism :

Peramivir, a cyclopentane analogue, selectively inhibits the influenza virus neuraminidase enzyme, preventing the release of viral particles from infected cells.

Indication :

  • Treatment of acute uncomplicated influenza in patients’ ≥2 years of age who have been symptomatic ≤2 days.

Contraindications :

Serious hypersensitivity or anaphylaxis to peramivir or any component of the formulation.

Dosing :

2 to 12 years:
12 mg/kg IV as a single dose; Maximum dose: 600 mg.
≥13 years:
600 mg as a single dose IV in uncomplicated and 600 mg once daily for 5 to 10 days in hospitalized, high risk patients.

Adverse Effect :

Hypertension, insomnia, hyperglycemia, diarrhea, constipation, vomiting, proteinuria, neutropenia, increased serum AST, ALT & CPK, fever.

Interaction :

Influenza Virus Vaccine (Live/Attenuated): Antiviral Agents may diminish the therapeutic effect of Influenza Virus Vaccine.

Hepatic Dose :

No dose adjustment recommended.
12/12/2023 17:55:41 Peramivir
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