Drug Index

Peramivir

 
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Mechanism :

Peramivir, a cyclopentane analogue, selectively inhibits the influenza virus neuraminidase enzyme, preventing the release of viral particles from infected cells.


Indication :

• Treatment of acute uncomplicated influenza in patients’ =2 years of age who have been symptomatic £2 days.


Contraindications :

Serious hypersensitivity or anaphylaxis to peramivir or any component of the formulation.


Dosing :

2 to 12 years: 12 mg/kg IV as a single dose; Maximum dose: 600 mg.

≥13 years: 600 mg as a single dose IV in uncomplicated and 600 mg once daily for 5 to 10 days in hospitalized, high risk patients.


Adverse Effect :

Hypertension, insomnia, hyperglycemia, diarrhea, constipation, vomiting, proteinuria, neutropenia, increased serum AST, ALT & CPK, fever.


Interaction :

Influenza Virus Vaccine (Live/Attenuated): Antiviral Agents may diminish the therapeutic effect of Influenza Virus Vaccine.


07/14/2019 07:10:35 Peramivir
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