Drug Index

Perampanel

 
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Mechanism :

Exact mechanism is not known. It is a non-competitive antagonist of AMPA glutamate receptor on postsynaptic neurons.


Indication :

• Partial-onset seizures: who are =4 years of age

• Primary generalized tonic-clonic seizures: who are =12 years of age.


Contraindications :

Hypersensitivity to perampanel or any component of the formulation.


Dosing :

Initial: 2 mg PO once daily at bedtime; may increase by 2 mg at weekly intervals. Maintenance dose: 8 to 12 mg PO once daily at bedtime.


Adverse Effect :

Peripheral edema, dizziness, hostility, aggressive behaviour, abnormal gait, fatigue, irritability, skin rash, weight gain, hyponatremia, vomiting, nausea, abdominal pain, constipation, UTI, bruise, back pain, URTI.


Interaction :

CNS Depressants: Perampanel may enhance the CNS depressant effect of CNS Depressants.
CYP3A4 Inducers: May decrease the serum concentration of Perampanel.
Mefloquine: May diminish the therapeutic effect of Anticonvulsants.
Selective Serotonin Reuptake Inhibitors: CNS Depressants may enhance the adverse/toxic effect of Selective Serotonin Reuptake Inhibitors.


07/17/2019 10:27:12 Perampanel
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