Drug Index


Mechanism :

Exact mechanism is not known. It is a non-competitive antagonist of AMPA glutamate receptor on postsynaptic neurons.

Indication :

  • Partial-onset seizures: who are Perampanel ≥4 years of age
  • Primary generalized tonic-clonic seizures: who are ≥12 years of age.

Contraindications :

Hypersensitivity to perampanel or any component of the formulation.

Dosing :

2 mg PO once daily at bedtime; may increase by 2 mg at weekly intervals. Maintenance dose: 8 to 12 mg PO once daily at bedtime.

Adverse Effect :

Peripheral edema, dizziness, hostility, aggressive behaviour, abnormal gait, fatigue, irritability, skin rash, weight gain, hyponatremia, vomiting, nausea, abdominal pain, constipation, UTI, bruise, back pain, URTI.

Interaction :

CNS Depressants: Perampanel may enhance the CNS depressant effect of CNS Depressants.
CYP3A4 Inducers: May decrease the serum concentration of Perampanel.
Mefloquine: May diminish the therapeutic effect of Anticonvulsants.
Selective Serotonin Reuptake Inhibitors: CNS Depressants may enhance the adverse/toxic effect of Selective Serotonin Reuptake Inhibitors.

Hepatic Dose :

Mild to moderate hepatic impairment: Start with 2 mg/day PO and then increase by 2 mg after 2 weeks based on patient’s response. The therapy should not exceed 6 mg/day for mild impairment and 4 mg/day for moderate impairment.
Severe hepatic impairment: Use is not recommended.
01/20/2024 13:43:20 Perampanel
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0