Drug Index


Mechanism :

Phentermine is a sympathomimetic amine. mechanism of action in reducing appetite appears to be secondary to CNS effects, including stimulation of the hypothalamus to release norepinephrine.

Indication :

  • Obesity (short-term adjunct)

Contraindications :

Hypersensitivity or idiosyncrasy to phentermine, other sympathomimetic amines or any component of the formulation; history of cardiovascular disease, hyperthyroidism; glaucoma; agitated states; history of drug abuse; use during or within 14 days following MAO inhibitor therapy; pregnancy; breast-feeding.

Dosing :

>16 years:
15 to 37.5 mg/day PO in 1 to 2 divided doses.

Adverse Effect :

Hypertension, ischemia, palpitations, tachycardia, Dizziness, dysphoria, euphoria, headache, insomnia, overstimulation, psychosis, restlessness, urticarial, change in libido, Constipation, diarrhea, gastrointestinal distress, unpleasant taste, xerostomia, tremor.

Interaction :

Alkalinizing Agents: May decrease the excretion of Amphetamines.
CYP2D6 Inhibitors: May increase the serum concentration of Amphetamines.
Iobenguane Radiopharmaceutical Products: Amphetamines may diminish the therapeutic effect of Iobenguane Radiopharmaceutical Products.
Monoamine Oxidase Inhibitors: May enhance the hypertensive effect of Amphetamines.
Opioid Analgesics: Amphetamines may enhance the analgesic effect of Opioid Analgesics.
Tricyclic Antidepressants: May enhance the stimulatory effect of Amphetamines.

Hepatic Dose :

No dosage adjustments are recommended.
01/19/2024 00:49:47 Phentermine
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0