Phentermine

Mechanism :

Phentermine is a sympathomimetic amine. mechanism of action in reducing appetite appears to be secondary to CNS effects, including stimulation of the hypothalamus to release norepinephrine.

Indication :

• Obesity (short-term adjunct)

Contraindications :

Hypersensitivity or idiosyncrasy to phentermine, other sympathomimetic amines or any component of the formulation; history of cardiovascular disease, hyperthyroidism; glaucoma; agitated states; history of drug abuse; use during or within 14 days following MAO inhibitor therapy; pregnancy; breast-feeding.

Dosing :

Adverse Effect :

Hypertension, ischemia, palpitations, tachycardia, Dizziness, dysphoria, euphoria, headache, insomnia, overstimulation, psychosis, restlessness, urticarial, change in libido, Constipation, diarrhea, gastrointestinal distress, unpleasant taste, xerostomia, tremor.

Interaction :

Alkalinizing Agents: May decrease the excretion of Amphetamines.
CYP2D6 Inhibitors: May increase the serum concentration of Amphetamines.
Iobenguane Radiopharmaceutical Products: Amphetamines may diminish the therapeutic effect of Iobenguane Radiopharmaceutical Products.
Monoamine Oxidase Inhibitors: May enhance the hypertensive effect of Amphetamines.
Opioid Analgesics: Amphetamines may enhance the analgesic effect of Opioid Analgesics.
Tricyclic Antidepressants: May enhance the stimulatory effect of Amphetamines.

Hepatic Dose :