Drug Index


Synonym :


Indication :

  • Antidote for the treatment of pesticides and chemicals poisoning (e.g., nerve agents) of the organophosphate class which have anticholinesterase activity.
  • Control of overdosage by anticholinesterase drugs used for myasthenia gravis treatment.

Dosing :

20-40 mg/kg IV/IM dissolved in 30-50 ml of normal saline over 30 minutes once a day till symptoms subside. Can be repeated in 1-2 hours if muscle weakness is not relieved. When symptoms subside it can be administered twice a day.

Adverse Effect :

Headache, dizziness, drowsiness, seizure, visual disturbances, tachycardia, hyperventilation, muscle weakness, nausea, hypertension, pain at injection site.

Fatal: Rapid administration causes tachycardia, laryngospasm and rigidity and large doses cause neuromuscular blockade.

Hepatic Dose :

No dosage adjustments are recommended.
01/23/2024 11:13:48 PAM
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0