Drug Index

Probenecid

 
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Mechanism :

It is a drug used in the acute treatment of gout as it increases the excretion of uric acid. which is responsible for gout disease. It is also used as an adjunct to antibiotic therapy.


Indication :

• Adjunct to antibiotic therapy to prolong penicillin levels


Contraindications :

Hypersensitivity to drug/class/component.

CrCl <50 , Uric acid nephrolithiasis, Blood dyscrasias, Acute gout attack.


Dosing :

<2 years: Contraindicated

>2 years:

<45 kg: Initially 25 mg/kg orally as a single dose or 0.7 g/sqm orally as a single dose to prolong penicillin levels; increase to 40 mg/kg/day in 6 hourly divided doses; Max dose: 500 mg/dose.

>45 kg: 500 mg orally four times daily.


Adverse Effect :

Nausea, vomiting, GI upset, flushing, hemolytic anaemia, aplastic anaemia, dyspepsia, convulsions, respiratory failure and rashes.


Interaction :

Probenecid: Increases plasma levels of penicillin and acyclovir.
Ketorolac: Avoid contamittant use with ketorolac since its half-life is increased 2-fold.


07/17/2019 20:42:34 Probenecid
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