Drug Index
Synonym :

Atovaquone/ Proguanil

Mechanism :

Proguanil is an antimalarial drug used mainly in the prophylaxis of falciparum malaria.

Indication :

  • Malaria prophylaxis and treatment along with atovaquone

Contraindications :

Hypersensitivity to drug/class/component, CrCl <30 (prophylaxis use).

Dosing :

Available as a 62.5 mg Atovaquone/25 mg Proguanil FDC (Pediatric strength) and 250 mg/100 mg Atovaquone/Proguanil FDC (Adult strength).
5-8 kg: 2 Pediatric tab OD
9-10 kg: 3 Pediatric tab OD
11-20 kg: 1 Adult tab OD
21-30 kg: 2 Adult tab OD
31-40 kg: 3 Adult tab OD
>40 kg: 4 Adult tab OD
Malaria prophylaxis:
11-20 kg: 1 Pediatric tablet daily
21-30 kg: 2 Pediatric tablets daily
31-40 kg: 3 Pediatric tablets daily
>40 kg: 4 Pediatric tablets daily
To be given 1 day before entering area and to be continued for 1 week after return. Contraindicated in pregnant women.

Adverse Effect :

Abdominal pain, headache, myalgia, nausea, increase LFTs, renal impairment, vertigo, rash, hematological abnormality.

Interaction :

Interaction Characteristics:
CYP2C19 substrate.
Auranofin, Gold sodium thiomalate.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-60100 mg daily
10-2050 mg every 48 hours
<1050 mg weekly

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in GFR=10–20 mL/min

Hepatic Dose :

No dosage adjustment required in mild to moderate hepatic impairment. No data available for use in severe hepatic impairment.
09/28/2020 07:22:19 Proguanil
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0