Drug Index



Mechanism :

Propylthiouracil is an anti-thyroid drug.

Indication :

• Hyperthyroidism

Contraindications :

Hypersensitivity or idiosyncratic reaction to propylthiouracil.

Dosing :

Neonates: Initially 5-10 mg/kg/day PO in 8 hourly divided doses.

<6 years: 5-7 mg/kg/day PO in 8 hourly divided doses initially.

6-10 years: 50-100 mg/day PO in 8 hourly divided doses.

>10 years: 150-300 mg/day.

Maintenance: Generally one-third or two-third of the initial; doses on the basis of response in 8-12 hourly divided doses.

Adverse Effect :

Agranulocytosis is the most serious potential side effect. It usually develops in the first few months of therapy, is dose related and is reversible on rapid withdrawal of the drug.

Leukopenia with granulocytopenia, hemolytic anemia, thrombocytopenia, hypoprothrom- binemia with hemorrhagic manifestations, aplastic anemia, myeloblastic leukemia, hyperglobulinemia, urticaria, pruritus, papular rash, loss or depigmentation of the hair, nausea, vomiting, abdominal discomfort, drowsiness, headache, dizziness, arthralgia and paresthesia occur occasionally. Maternal ingestion in pregnancy can lead to fetal goitre.

Interaction :

Increased sensitivity to warfarin has been observed in hyperthyroidism and careful control of dosage is required as the patient is rendered euthyroid.
Changes in thyroid state may affect response to digoxin, theophylline, beta-blockers and insulin.

01/30/2020 05:55:07 Propylthiouracil
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