Drug Index

Rasburicase

 
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Mechanism :

Rasburicase is a recombinant urate-oxidase enzyme, which converts uric acid to allantoin.


Indication :

• Hyperuricemia associated with malignancy


Contraindications :

History of anaphylaxis or severe hypersensitivity to rasburicase or any component of the formulation; history of hemolytic reaction or methemoglobinemia associated with rasburicase; glucose-6-phosphatase dehydrogenase (G6PD) deficiency.


Dosing :

IV: 0.2 mg/kg once daily for up to 5 days.


Adverse Effect :

Peripheral edema, headache, anxiety, rash, hypophosphatemia, hypervolemia, nausea, vomiting, abdominal pain, hyperbilirubinemia, increased serum ALT, antibody development, sepsis, fever.


Interaction :

No known significant interactions.


07/21/2019 22:35:38 Rasburicase
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