Drug Index

Rasburicase

 
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Mechanism :

Rasburicase is a recombinant urate-oxidase enzyme, which converts uric acid to allantoin.


Indication :

• Hyperuricemia associated with malignancy


Contraindications :

History of anaphylaxis or severe hypersensitivity to rasburicase or any component of the formulation; history of hemolytic reaction or methemoglobinemia associated with rasburicase; glucose-6-phosphatase dehydrogenase (G6PD) deficiency.


Dosing :

IV: 0.2 mg/kg once daily for up to 5 days.


Adverse Effect :

Peripheral edema, headache, anxiety, rash, hypophosphatemia, hypervolemia, nausea, vomiting, abdominal pain, hyperbilirubinemia, increased serum ALT, antibody development, sepsis, fever.


Interaction :

No known significant interactions.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDUnlikely to be dialysed. Dose as in normal renal function
HDF/High fluxUnlikely to be dialysed. Dose as in normal renal function
CAV/VVHDUnlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

No dose adjustment recommended.
05/21/2020 22:21:07 Rasburicase
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