Drug Index



Mechanism :

Rifaximin inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase.

Indication :

• Hepatic Encephalopathy

• Irritable bowel syndrome with diarrhea

• Traveller’s diarrhea in children =12 years of age

Contraindications :

Hypersensitivity to rifaximin, other rifamycin antibiotics, or any component of the formulation.

Dosing :

Safety and efficacy has not been established in children <12 years.

Hepatic encephalopathy:

Adults: 400 mg PO every 8 hours for 5 to 10 days.

Traveler’s diarrhea:

>12 years: 200 mg PO 3 times daily for 3 days.

Irritable bowel syndrome with diarrhea:

Adults: 550 mg 3 times daily for 14 days.

Adjunct therapy for C.difficile infection:

>12 years: 200 mg PO 3 times daily for 20 days. Max: 400 mg/dose.

Adverse Effect :

Peripheral edema, dizziness, fatigue, ascites, nausea, depression, pruritus, abdominal pain, pseudomembranous colitis, anemia, muscle spasms, arthralgia, fever.

Interaction :

Cyclosporine: May increase the serum concentration of rifaximin.
P-glycoprotein/ABCB1 Inhibitors: May increase the serum concentration of rifaximin.

01/30/2020 06:13:04 Rifaximin
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