Drug Index

Rifaximin

 
print

Mechanism :

Rifaximin inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase.


Indication :

• Hepatic Encephalopathy

• Irritable bowel syndrome with diarrhea

• Traveller’s diarrhea in children =12 years of age


Contraindications :

Hypersensitivity to rifaximin, other rifamycin antibiotics, or any component of the formulation.


Dosing :

Safety and efficacy has not been established in children <12 years.

Hepatic encephalopathy:

Adults: 400 mg PO every 8 hours for 5 to 10 days.

Traveler’s diarrhea:

>12 years: 200 mg PO 3 times daily for 3 days.

Irritable bowel syndrome with diarrhea:

Adults: 550 mg 3 times daily for 14 days.

Adjunct therapy for C.difficile infection:

>12 years: 200 mg PO 3 times daily for 20 days. Max: 400 mg/dose.


Adverse Effect :

Peripheral edema, dizziness, fatigue, ascites, nausea, depression, pruritus, abdominal pain, pseudomembranous colitis, anemia, muscle spasms, arthralgia, fever.


Interaction :

Cyclosporine: May increase the serum concentration of rifaximin.
P-glycoprotein/ABCB1 Inhibitors: May increase the serum concentration of rifaximin.


07/13/2019 00:32:37 Rifaximin
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0