Drug Index


Mechanism :

Sacrosidase is a naturally-occurring gastrointestinal enzyme derived from baker's yeast (Saccharomyces cerevisiae) which breaks down the disaccharide sucrose to its monosaccharide components.

Indication :

  • Oral replacement therapy in sucrase deficiency, as seen in congenital sucrase isomaltase deficiency (CSID)

Contraindications :

Hypersensitivity to yeast, yeast products, glycerine (glycerol), or papain.

Dosing :

Infants ≥5 months and Children ≤15 kg:
Oral: 8,500 units (1 mL) per meal or snack.
Children >15 kg and Adolescents:
Oral: 17,000 units (2 mL) per meal or snack.

Adverse Effect :

Headache, insomnia, nervousness, dehydration, abdominal pain, constipation, diarrhea, nausea, vomiting.

Interaction :

No known significant interactions.

Hepatic Dose :

No dose adjustment recommended.
02/13/2024 17:15:32 Sacrosidase
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