Sacrosidase
Mechanism :
Sacrosidase is a naturally-occurring gastrointestinal enzyme derived from baker's yeast (Saccharomyces cerevisiae) which breaks down the disaccharide sucrose to its monosaccharide components.
Indication :
- Oral replacement therapy in sucrase deficiency, as seen in congenital sucrase isomaltase deficiency (CSID)
Contraindications :
Hypersensitivity to yeast, yeast products, glycerine (glycerol), or papain.
Dosing :
Infants ≥5 months and Children ≤15 kg:
Oral: 8,500 units (1 mL) per meal or snack.
Children >15 kg and Adolescents:
Oral: 17,000 units (2 mL) per meal or snack.
Adverse Effect :
Headache, insomnia, nervousness, dehydration, abdominal pain, constipation, diarrhea, nausea, vomiting.
Interaction :
No known significant interactions.
Hepatic Dose :
No dose adjustment recommended.