Drug Index

Segesterone/Ethinyl Estradiol

 
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Mechanism :

It is a combined hormonal contraceptive (CHC). CHCs lower the risk of becoming pregnant primarily by suppressing ovulation.
Ethinyl estradiol (EE): Reduces LHRH release from hypothalamus, reduces gonadotropin release from pituitary.
Segesterone acetate (SA): Progestin; inhibits gonadotropin secretion from pituitary; prevents follicular maturation and ovulation.


Indication :

• Contraceptive


Contraindications :

Hypersensitivity to segesterone, ethinyl estradiol, or any component of the formulation; current or history of breast cancer or other estrogen- or progestin-sensitive cancer; liver tumors, acute hepatitis, or severe (decompensated) cirrhosis; undiagnosed abnormal uterine bleeding; hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir.


Dosing :

Available as silicone elastomer vaginal system: 103 mg/17.4 mg.

Place one vaginal system in the vagina and it should remain in place continuously for 21 days. After 3 weeks, remove the vaginal system for 1 week for a dose-free interval, during which a withdrawal bleed usually occurs.


Adverse Effect :

Headache, migraine, nausea, vomiting, abdominal pain, vulvovaginal candidiasis, dysmenorrhea, vaginal discharge, deep vein thrombosis, psychiatric disturbance, genital pruritus, heavy menstrual bleeding, breakthrough bleeding, breast tenderness, pyelonephritis.


Interaction :

Anticoagulants: Estrogen Derivatives and progestins may diminish the anticoagulant effect of Anticoagulants.
Antihepaciviral Combination Products: Ethinyl Estradiol may enhance the hepatotoxic effect of Antihepaciviral Combination Products.
Barbiturates: May diminish the therapeutic effect of Estrogen Derivatives and progestins.
Corticosteroids: Estrogen Derivatives may increase the serum concentration of Corticosteroids.
CYP3A4 Inducers: May increase the metabolism of CYP3A4 Substrates.
CYP3A4 Inhibitors: May increase the serum concentration of Estrogen Derivatives and progestins.
Phenytoin: May diminish the therapeutic effect of Estrogen Derivatives and progestins.


07/18/2019 11:47:48 Segesterone/Ethinyl Estradiol
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