Drug Index

Sodium Aurothiomalate

 
print

Mechanism :

Unknown. May decrease prostaglandin synthesis or may alter cellular mechanisms by inhibiting sulfhydryl systems.


Indication :

• Adjunctive treatment of active rheumatoid arthritis


Contraindications :

Hypersensitivity to gold compounds or any component of the formulation; history of severe toxicity to gold compounds or heavy metals; systemic lupus erythematosus; severe debilitation.


Dosing :

Give a test dose of 10 mg IM. Then give 1 mg/kg IM every week (Maximum: 50 mg/injection) until signs of remission appear then increase the intervals between injections to two weeks. With full remission increase the interval to 3-4 weeks. In the absence of signs of remission after twenty weeks consider raising the dose slightly or changing to another therapy. If patients respond, maintenance therapy should be continued with 3-4 weeks interval for 1-5 years.


Adverse Effect :

Bradycardia, syncope, vasomotor symptoms, confusion, Guillain-Barre syndrome, hallucination, metallic taste, peripheral neuropathy, seizure, alopecia, dermatitis, onycholysis, pruritus, anorexia, abdominal cramps, cholestasis, diarrhea, hematuria, nephrotic syndrome, proteinuria, agranulocytosis, aplastic anemia, eosinophilia, leukopenia, purpura, thrombocytopenia, anaphylactoid reaction, anaphylaxis, angioedema, tongue edema, hepatitis, hepatotoxicity, jaundice, conjunctivitis, corneal ulcer, iritis, dyspnea, interstitial pneumonitis, pulmonary fibrosis.


Interaction :

Angiotensin-Converting Enzyme Inhibitors: May enhance the adverse/toxic effect.


08/08/2019 17:22:23 Sodium Aurothiomalate
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0