Drug Index

Sodium Bicarbonate

Mechanism :

Sodium Chloride is source of water and electrolytes. It is capable of inducing diuresis depending on the clinical condition of the patient. It is a crystalloid given intravenously in case of shock, dehydration, and diarrhoea to increase the plasma volume.

Indication :

  • Metabolic acidosis

Contraindications :

Contraindicated in any situation where salt retention is undesirable such as edema, heart disease, cardiac decompensation and primary or secondary aldosteronism.

Dosing :

Individualise the dose as per the formula:
0.6 x weight x deficit IV/PO.

Adverse Effect :

Local reactions which may occur due to injection are infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation, and hypervolemia.

Interaction :

Corticosteroids or Corticotropin: Caution must be exercised in the administration of Sodium Chloride.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. Dose as in normal renal function
HDDialysed. Dose as in normal renal function
HDF/High fluxDialysed. Dose as in normal renal function
CAV/VVHDDialysed. Dose as in normal renal function

Hepatic Dose :

No dose adjustment recommended. Use cautiously if there is concurrent presence of retention of sodium and edema.
01/19/2024 00:33:17 Sodium Bicarbonate
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