Drug Index

Sumatriptan

 
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Mechanism :

Sumatriptan is an agonist for 5-hydroxytryptamine1 receptor subtype having only a weak affinity for 5-HT1A, 5-HT5A, and 5-HT7 receptors and no significant affinity for 5-HT2, 5-HT3 or 5-HT4 receptor subtypes or at alpha1-, alpha2-, or beta-adrenergic, dopamine1; dopamine2; muscarinic, or benzodiazepine receptors.


Indication :

• Acute attack of Migraine


Contraindications :

Contraindicated in patients with history, symptoms, or signs of ischemic cardiac, cerebrovascular, or peripheral vascular syndromes, all forms of myocardial infarction, and silent myocardial ischemia, coronary vasospasm and uncontrolled hypertension.


Dosing :

Oral: As single dose.

6-10 years: 25 mg

10-12 years: 50 mg

12-18 years: 50-100 mg


Adverse Effect :

Rarely serious cardiac events, including some that have been fatal, have occurred following the use of sumatriptan including coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, ventricular fibrillation, nausea, vomiting, seizures, transient tingling sensation, heaviness, flushing, dizziness, weakness and hypersensitivity reactions.


Interaction :

MAO-A Inhibitors: Reduce sumatriptan clearance, significantly increasing systemic exposure. Therefore, the use of sumatriptan tablets in patients receiving MAO-A inhibitors is contraindicated.
Selective Serotonin Reuptake Inhibitors Fluoxetine, Fluvoxamine, Paroxetine, Sertraline: Rarely cause weakness, hyperreflexia, and incoordination when coadministered with sumatriptan.


07/17/2019 21:40:43 Sumatriptan
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