Drug Index

Tolazoline

 
print

Mechanism :

An alpha-adrenergic blocking agent, tolazoline HCl is structurally related to phentolamine. By directly relaxing vascular smooth muscle, tolazoline has peripheral vasodilating effects and decreases total peripheral resistance. Tolazoline also is a competitive alpha1 and alpha2 adrenergic blocking agent.


Indication :

• Reduce pulmonary vascular resistance in newborn.

• Improve pulmonary circulation in ventilated babies.


Contraindications :

Cardiotoxic accumulation can occur quite rapidly in babies with renal failure when tolazoline is given by continuous infusion. Babies given a continuous tolazoline infusion must have their blood pressure measured periodically.


Dosing :

Loading dose IV: 1-2 mg/kg given over 10 minutes. Observe infant for 30 minutes. If a positive response occurs (increased pO2), commence maintenance therapy.

Maintenance dose IV infusion: 1-2 mg/kg/hour. Note: Correct acidosis and hypovolemia prior to administration, infuse through a scalp vein, pulmonary artery catheter, or right upper extremity vein, titrate dose to desired effect.

Doses >5 mg/kg/hour are not likely to increase efficacy. Titrate to discontinue.


Adverse Effect :

Transient tachycardia; peripheral vasodilatation presenting as sweating, hyperalgesia of the lips, piloerection; clear lacrimal and nasal discharge; muscle fasciculation; apprehensiveness. Adverse effects should diminish with time and generally disappear within 2 hours of dosing.


Interaction :

Norepinephrine, Epinephrine: A paradoxical drop in blood pressure can occur followed by a precipitous increase in blood pressure.
Alcohol: Accumulation of acetaldehyde can occur.


07/19/2019 03:09:47 Tolazoline
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0