Drug Index

Treprostinil

 
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Mechanism :

Treprostinil is a direct vasodilator of both pulmonary and systemic arterial vascular beds; also inhibits platelet aggregation.


Indication :

• Pulmonary arterial hypertension


Contraindications :

Injection/inhalation: No contraindications

Oral: Severe hepatic impairment (Child-Pugh class C).


Dosing :

Injectable (≥16 years): Initial: 1.25 ng/kg/min continuous SC/IV infusion (0.625 ng/kg/min if not tolerated).

Titrate by no more than 1.25 ng/kg/min every week x first 4 weeks, then no more than 2.5 ng/kg/min every week. Max: 40 ng/kg/min.

Oral tablet (≥18 years): Initial: 0.25 mg PO BID with food, taken ~12 hours apart. Increase dose as tolerated to achieve optimal clinical response by increments or 0.25-0.5 mg BID every 3-4 days.


Adverse Effect :

Infusion site reaction, pain, headache, nausea, diarrhea, vasodilation, jaw pain, rash, dizziness, edema, pruritus, hypotension.


Interaction :

CYP2C8 Inhibitors (Strong): May increase the serum concentration of Treprostinil.
Rifampin: May decrease the serum concentration of Treprostinil.
Thrombolytic Agents: May enhance the adverse/toxic effect of Prostacyclin Analogues.


07/21/2019 21:55:29 Treprostinil
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