Drug Index

Triptorelin

 
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Mechanism :

Triptorelin is an agonist analog of gonadotropin releasing hormone (GnRH) and causes suppression of ovarian and testicular steroidogenesis.


Indication :

• Central precocious puberty


Contraindications :

Known hypersensitivity to triptorelin or any component of the formulation, other GnRH agonists or GnRH; pregnancy.


Dosing :

Children ≥2 years: 22.5 mg IM once every 24 weeks. Discontinue therapy at appropriate age of onset of puberty.


Adverse Effect :

Hot flushes, skeletal pain, injection site pain and redness, nasopharyngitis, headache, impotence, vaginal bleeding.


Interaction :

Amiodarone, Anagrelide, Dofetilide: Triptorelin increases toxicity by prolonging QTc interval. Contraindicated. Increases risk of torsades de pointes.
Antidiabetic Agents: Hyperglycemia-Associated Agents may diminish the therapeutic effect of Antidiabetic Agents.


07/18/2019 02:00:10 Triptorelin
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