Drug Index

Valsartan

 
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Mechanism :

Valsartan, an angiotensin II receptor antagonist, produces its BP lowering effects by antagonizing angiotensin II-induced vasoconstriction, aldosterone release and renal reabsorption of sodium.


Indication :

• Hypertension


Contraindications :

Hypersensitivity; Severe hepatic impairment; Cirrhosis or biliary obstruction; Primary hyperaldosteronism.


Dosing :

<6 years: Safety and efficacy not established

>6 years: 0.65-1.3 mg/kg/dose twice daily. Increase upto 40 mg/day. Maximum dose: 160 mg/day. In adults, maximum dose is 320 mg/day.


Adverse Effect :

Dizziness, headache, dose-related orthostatic hypotension, rash, angioedema, hyperkalaemia, myalgia, dry cough, back pain, fatigue, GI disturbances, abdominal pain, LFT elevations, increase in BUN and serum creatinine, blood dyscrasias (e.g. neutropenia).


Interaction :

NSAIDs and Ciclosporin: Increased risk of renal impairment and hyperkalaemia with NSAIDs and ciclosporin.
General Anaesthetics, Clozapine, Dopamine agonists and other Antihypertensives: Increased risk of hypotension.

Lithium: Increased risk of lithium toxicity.
Potassium-Sparing Diuretics, Potassium Supplements, ACE Inhibitors, Heparin: Increased risk of hyperkalaemia.


07/17/2019 21:28:21 Valsartan
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