Pyrethrins And Pyrethroids - Poisoning Center

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Poisning Center › Agricultural poisons › Pyrethrins and pyrethroids

Pyrethrins and pyrethroids

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They are extracted from chrysanthemum plant and used as insect repellants and pesticides. They are available as sprays, dusts, powders and mats
Route :
Ingestion, inhalation, skin contact
Fatal Dose :
1gm/kg body weight
Fatal Period :
2 to 5 days
Mechanism of action :
They prolong the inactivation of sodium channel by binding it in the inactive state
Clinical Picture :
•Skin contact causes dermatitis and blistering •Paraesthesias, nausea, vomiting, and diarrhea •Inhalation causes rhinorrhea, sore throat, wheezing and dyspnoea •Fasciculations, hyperthermia, altered mental status •Convulsions and coma
Treatment :
•Gastric lavage with activated charcoal •Oils and fats to be avoided •Atropine and oximes are contraindicated •Skin should be washed

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