Celiac Disease

Himali Meshram
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INTRODUCTION
Celiac Disease (CD) is an immune-mediated disease caused by exposure to gluten and related prolamines. It occurs in individuals who are genetically predisposed. It leads to diarrhea and malabsorption of most nutrients and vitamins. Patients can also present with anemia and short stature.

Celiac disease occurs in genetic predisposed individuals on exposure to gluten due to immunologically based inflammation that leads to intestinal maldigestion. It is strongly associated with the HLA phenotypes DQ8, DR3, and DQ2. The most important environmental factor in celiac disease is gluten found in wheat, barley, rye, oats. The inflammatory
response consists of increased numbers of lymphocytes, plasma cells, and macrophages in the lamina propria and increased numbers of lymphocytes in the surface layer of the epithelium of the intestines.


Celiac Disease Celiac Disease 09/04/2018
SIGNS AND SYMPTOMS >>
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