Drug Index

Alendronate

 
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Synonym :

Alendronic acid

Mechanism :

Alendronic acid reduces bone resorption by inhibiting the action of osteoclasts.


Indication :

• Osteoporosis,

• Osteogenesis Imperfecta and

• Bone manifestations of Gaucher’s Disease.


Contraindications :

Hypocalcaemia; oesophageal abnormalities and factors which delay oesophageal emptying; severe renal impairment; hypersensitivity; inability to stand or sit upright for atleast 30 min.


Dosing :

Safety and efficacy not established in children. Use in children >2 years orally.

≤30 kg: 5 mg once daily.

30 to <40 kg: 5 or 10 mg once daily.

≥40 kg: 10 mg once daily.


Adverse Effect :

Hypocalcemia (transient and mild), esophagitis, esophageal ulcers and erosions, dysphagia, heartburn, retrosternal pain, abdominal pain, distension, diarrhea, constipation, flatulence, rash, erythema, musculoskeletal pain, transient hypophosphatemia.


Interaction :

Concomitant iron, calcium supplements and antacids hinder alendronate absorption.

Concomitant aspirin or NSAIDs may increase the incidence of adverse GI effects.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
35-50Dose as in normal renal function
<35Avoid.

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in GFR<35 mL/min
HDNot dialysed. Dose as in GFR<35 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<35 mL/min
CAV/VVHDUnlikely to be dialysed. Dose as in GFR<35 mL/min

Hepatic Dose :

No dosage adjustments are recommended.
07/29/2020 01:25:02 Alendronate
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