Drug Index

Alendronate

 
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Synonym :

Alendronic acid

Mechanism :

Alendronic acid reduces bone resorption by inhibiting the action of osteoclasts.


Indication :

• Osteoporosis,

• Osteogenesis Imperfecta and

• Bone manifestations of Gaucher’s Disease.


Contraindications :

Hypocalcaemia; oesophageal abnormalities and factors which delay oesophageal emptying; severe renal impairment; hypersensitivity; inability to stand or sit upright for atleast 30 min.


Dosing :

Safety and efficacy not established in children. Use in children >2 years orally.

≤30 kg: 5 mg once daily.

30 to <40 kg: 5 or 10 mg once daily.

≥40 kg: 10 mg once daily.


Adverse Effect :

Hypocalcemia (transient and mild), esophagitis, esophageal ulcers and erosions, dysphagia, heartburn, retrosternal pain, abdominal pain, distension, diarrhea, constipation, flatulence, rash, erythema, musculoskeletal pain, transient hypophosphatemia.


Interaction :

Concomitant iron, calcium supplements and antacids hinder alendronate absorption.

Concomitant aspirin or NSAIDs may increase the incidence of adverse GI effects.


07/14/2019 19:34:10 Alendronate
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