Sodium Bicarbonate
Mechanism :
Sodium Chloride is source of water and electrolytes. It is capable of inducing diuresis depending on the clinical condition of the patient. It is a crystalloid given intravenously in case of shock, dehydration, and diarrhoea to increase the plasma volume.
Indication :
Contraindications :
Contraindicated in any situation where salt retention is undesirable such as edema, heart disease, cardiac decompensation and primary or secondary aldosteronism.
Dosing :
Individualise the dose as per the formula:
0.6 x weight x deficit IV/PO.
Adverse Effect :
Local reactions which may occur due to injection are infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation, and hypervolemia.
Interaction :
Corticosteroids or Corticotropin: Caution must be exercised in the administration of Sodium Chloride.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 20-50 | Dose as in normal renal function |
| 10-20 | Dose as in normal renal function |
| <10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Dialysed. Dose as in normal renal function |
| HD | Dialysed. Dose as in normal renal function |
| HDF/High flux | Dialysed. Dose as in normal renal function |
| CAV/VVHD | Dialysed. Dose as in normal renal function |
Hepatic Dose :
No dose adjustment recommended. Use cautiously if there is concurrent presence of retention of sodium and edema.