Drug Index

Niclosamide

 
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Mechanism :

Niclosamide is an anthelmintic drug that uncouples oxidative phosphorylation in the tapeworm.


Indication :

• Tapeworm infestation


Contraindications :

Contraindicated in known hypersensitivity to niclosamide.


Dosing :

Taenia solium (pork), Taenia saginata (beef), Diphyllobothrium latum (fish):

Oral. Once daily. For the latter 2 tapeworms, could give in 2 divided doses one before breakfast and then 1 hour later.

<2 years: 500 mg

2-6 years: 1 gm

>7 years: 2 gm

Hymenolepis nana (dwarf tapeworm):

Oral. Single dose on first day followed by half that dose daily once for the next 6 days.

lnitial dose for <2 years, 2-6 years and 7-18 years are 500 mg, 1 gm and 2 gm respectively.


Adverse Effect :

Nausea, retching and abdominal pain, light-headedness, pruritus.


Interaction :

Alcohol: May possibly increase the side-effects of niclosamide.


07/14/2019 20:12:10 Niclosamide
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