Drug Index

Thiabendazole

 
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Mechanism :

Tiabendazole, a benzimidazole derivative, has activity against most nematode worms, larval stages and ova. Its mechanism is uncertain but may inhibit fumarate-reductase system of worms, hence interfering with their source of energy. It also has some antifungal activity.


Indication :

• Cutaneous larvae migrans

• Guinea worm

• Trichiniasis


Contraindications :

Mixed worm infections involving Ascaris lumbricoides. Prophylactic treatment for enterobiasis infection.


Dosing :

Use in children 2 years and above.

Angiostrongylosis:

25 mg/kg (up to 1 g) orally 3 times a day for 3 days.

Capillariasis:

25 mg/kg (up to 3 g) orally once a day for 30 days.

Strongyloidosis:

25 mg/kg/2 times a day for 2 successive days. Alternatively, a single dose of 50 mg/kg once.

Dracunculiasis:

25 to 37.5 mg/kg (up to 1.5 g) orally 2 times a day for 3 days.

Visceral Larva Migrans (Toxocariasis):

25 mg/kg (up to 1 g) orally 2 times a day for 7 successive days. Max daily dose: 3 g.

Trichostrongylosis, Cutaneous Larva Migrans, Trichinosis:

25 mg/kg (up to 1.5 g) orally 2 times a day for 2 days.


Adverse Effect :

Dizziness; GI disturbances; pruritus, skin rashes; drowsiness, headache, fatigue, drying of mucous membrane; hyperglycaemia, visual disturbances; leukopenia; tinnitus; hepatic effects; enuresis; crystalluria; bradycardia; hypotension. Transient increase in liver test.

Potentially Fatal: Fatal Stevens-Johnson syndrome, erythema multiforme. Toxic epidermal necrolysis, liver damage.


Interaction :

Potentially Fatal: Concurrent use inhibits metabolism of theophylline and caffeine. Possible increase in anticoagulant effect with coumarins.


07/18/2019 12:00:04 Thiabendazole
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