Drug Index

Chlorpromazine

 
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Mechanism :

The precise mechanism of action of Chlorpromazine is not known. The principal pharmacological actions are psychotropic. It also exerts sedative and antiemetic activity. Chlorpromazine has actions at all levels of the central nervous system, primarily at subcortical levels, as well as on multiple organ systems. Chlorpromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.


Indication :

• Schizophrenia

• Mania

• Agitation

• Hiccups

• Behavioural disorder, hyperactivity

• Narcotic withdrawal

• Nausea and vomiting


Contraindications :

Do not use in patients with known hypersensitivity to phenothiazines. Do not use in comatose states or in the presence of large amounts of central nervous system depressants like alcohol, barbiturates and narcotics.


Dosing :

Behavioral disorders:

5 months-12 years: 2.5-6 mg/kg/day PO QDS or 2.5-4 mg/kg/day IM 6-8 hourly, (Maximum 50 mg/day PO and 40 mg/day IM in 6 months-5 years; maximum 200 mg/day PO and 75 mg/day in 5-12 years).

12-18 years: 200-400 mg/day PO in 3-4 doses, can increase every 3rd day to max 1000 mg/day.

Intractable hiccup/Acute intermittent porphyria:

6-12 years: 10 mg/dose 1-3 times daily.

12-18 years: 25-50 mg/dose PO 3-4 times daily.

Nausea and vomiting:

≥6 months-12 years: 0.55 mg/kg oral/IM every 6-8 hours (Maximum 50 mg/day PO and 40 mg/day IM in 6 months-5 years; maximum 200 mg/day PO and 75 mg/day in 5-12 years)

12-18 years: 10-25 mg PO/IM every 4-6 hours, can increase every 3rd day to max 1000 mg/day.

For pre-op to prevent nausea/vomiting:

≥6 months-12 years: 0.25 mg/kg IM ½ hour before procedure or 2 mg IV 2-5 mins before procedure.

12-18 years: 12.5 mg/kg IM ½ hour before procedure or 1 mg IV 2-5 mins before procedure.

Adjunct treatment in tetanus:

≥6 months-12 years: 0.5 mg/kg IM/IV every 6-8 hours. Maximum 40 mg/day IM in

6 months-5 years; maximum 75 mg/day in 5-12 years.

12-18 years: 25-50 IM every 6-8 hours


Adverse Effect :

Extrapyramidal symptoms, anti-muscarinic effects, erectile dysfunction, oligomenorrhoea or amenorrhea, weight gain.


Interaction :

Astemizole, Stall, Cisapride, Indapamide, Procainamide, Quinidine: Increase QT interval.


08/06/2019 12:21:10 Chlorpromazine
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