Indication :
• Chemotherapy induced nausea and vomiting
Dosing :
>6 months: 3 mg/kg (Max: 125 mg) orally 1 hour prior to chemotherapy. On 2nd and 3rd day of chemotherapy, give 2 mg/kg (Max: 80 mg).
Adverse Effect :
Rash, urticaria, Steven Johnson syndrome, headache, malaise, constipation, drowsiness, fever, dizziness, arrhythmias, QTc prolongation, anaphylaxis, elevated transaminases, oculogyric crises.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 20-50 | Dose as in normal renal function |
| 10-20 | Dose as in normal renal function |
| <10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Not dialysed. Dose as in normal renal function. |
| HD | Not dialysed. Dose as in normal renal function |
| HDF/High flux | Unlikely to be dialysed. Dose as in normal renal function |
| CAV/VVHD | Not dialysed. Dose as in normal renal function |
Hepatic Dose :
Mild to moderate hepatic impairment: No dosage adjustments required.
Severe hepatic impairment: Use with caution and monitor closely.