Drug Index

Aprepitant

 
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Indication :

• Chemotherapy induced nausea and vomiting


Dosing :

>6 months: 3 mg/kg (Max: 125 mg) orally 1 hour prior to chemotherapy. On 2nd and 3rd day of chemotherapy, give 2 mg/kg (Max: 80 mg).


Adverse Effect :

Rash, urticaria, Steven Johnson syndrome, headache, malaise, constipation, drowsiness, fever, dizziness, arrhythmias, QTc prolongation, anaphylaxis, elevated transaminases, oculogyric crises.


Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function.
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnlikely to be dialysed. Dose as in normal renal function
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

Mild to moderate hepatic impairment: No dosage adjustments required.
Severe hepatic impairment: Use with caution and monitor closely.
08/03/2020 16:29:11 Aprepitant
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