Beclomethasone

Mechanism :

Beclomethasone dipropionate is a diester of beclomethasone, a synthetic corticosteroid chemically related to dexamethasone. Corticosteroids have multiple anti-inflammatory effects, inhibiting both inflammatory cells and release of inflammatory mediators. It is presumed that these anti-inflammatory actions play an important role in the efficacy of beclomethasone dipropionate in controlling symptoms and improving lung function in asthma.

Indication :

• Prophylaxis of asthma
• Prophylaxis and treatment of allergic rhinitis

Contraindications :

Beclomethasone can occasionally cause paradoxical bronchospasm. Use with caution in respiratory infection.

Dosing :

Adverse Effect :

Urticaria, angioedema, rash, and bronchospasm, systemic adrenal suppression, oral candidiasis (with inhalers).

Interaction :

Interactions like other corticosteroids amongst which the most significant recently is:
Inhaled corticosteroids are substrates of hepatic CYP3A4 and have the potential to interact with ritonavir. These interactions can result in steroid accumulation, adrenal suppression and Cushing's syndrome.

Hepatic Dose :