Drug Index

Clobetasol

 
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Mechanism :

Clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.


Indication :

• Relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.


Contraindications :

Contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.


Dosing :

Available as 0.05%/0.1%/10 gm cream.

Apply a thin layer of cream or ointment to the affected skin areas twice daily.


Adverse Effect :

Burning and stinging sensation, skin atrophy, cracking and fissuring of the skin.


Interaction :

No significant interactions found.


08/11/2019 20:46:00 Clobetasol
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